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The Per01 mutant flies showed altered circadian rhythm when compared to non-mutated flies and they had reduced life span, elevated oxidative damage, and degeneration of neurons ( Sod-1, GPx-1, Cat , show the E-box elements implying that these genes are regulated by BMAL1:CLOCK complex transcriptionally ( Mus booduga mouse, showed that there was a disruption of the circadian clock in the mouse and these effects could be reversed by melatonin (Verma et al., 2014)

discussion 425-6, 2002

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